Onycholysis is when nails separate from the nail bed. This can be caused by medications or harsh chemicals, but sometimes signals thyroid problems. The separation usually starts at the nail tip and moves toward the cuticle, creating a white or opaque area. Other causes include psoriasis, fungal infections, trauma, and some medications, especially tetracycline antibiotics. Frequent manicures or long exposure to water can make it worse. Treatment depends on the cause but often involves keeping nails dry and clean, avoiding activities that worsen the problem, and letting the nail grow out. For cases linked to conditions like thyroid disease, treating the underlying issue is key to stopping it from happening again.